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Article

Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants Differently Affect Keratinocyte Proliferation and Apoptosis.

The Journal of investigative dermatology - 1 Sept 2021

Shulepko Mikhail A, Bychkov Maxim L, Shenkarev Zakhar O, Kulbatskii Dmitrii S, Makhonin Alexey M, Paramonov Alexander S, Chugunov Anton O, Kirpichnikov Mikhail P, Lyukmanova Ekaterina N

Abstract excerpt

Mal de Meleda is an autosomal recessive palmoplantar keratoderma associated with mutations in a gene encoding SLURP-1. SLURP-1 controls growth, differentiation, and apoptosis of keratinocytes by interaction with α7-type nicotinic acetylcholine receptors. SLURP-1 has a three-finger structure with a β-structural core (head) and three prolonged loops (fingers). To determine the role of SLURP-1 mutations, we produced...

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Share to alpha7 Nicotinic Acetylcholine Receptor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Keratinocytes

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Identifiers

PMID: 33741389
DOI: 10.1016/j.jid.2021.01.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants Differently Affect Keratinocyte Proliferation and Apoptosis.PMID 33741389Read ↗

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