Article
Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling.
Molecular cancer - 26 Sept 2006
Ruano Yolanda, Mollejo Manuela, Ribalta Teresa, Fiaño Concepción, Camacho Francisca I, Gómez Elena, de Lope Angel Rodríguez, Hernández-Moneo Jose-Luis, Martínez Pedro, Meléndez Bárbara
Abstract excerpt
BACKGROUND: Conventional cytogenetic and comparative genomic hybridization (CGH) studies in brain malignancies have shown that glioblastoma multiforme (GBM) is characterized by complex structural and numerical alterations. However, the limited resolution of these techniques has precluded the precise identification of detailed specific gene copy number alterations. RESULTS: We performed a genome-wide survey of...
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