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Article

Role of Human Placental Efflux Transporter P-Glycoprotein in the Transfer of Buprenorphine, Levo-α-Acetylmethadol, and Paclitaxel

1 Sept 2006

Abstract excerpt

This study examines the role of placental P-glycoprotein (P-gp) in the transfer of buprenorphine (BUP) and L-alpha-acetylmethadol (LAAM) across the dually perfused human placental lobule. BUP (10 ng/mL) and LAAM (35 ng/mL) were perfused in the maternal-to-fetal direction. The following kinetic parameters were determined: fetal transfer rate (TR (f)), maternal clearance (Cl (m)), and clearance index (Cl (index))....

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Identifiers

PMID: 17001553
DOI: 10.1055/s-2006-951301

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