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Article

Relationship of glutathione S-transferase genotypes with side-effects of pulsed cyclophosphamide therapy in patients with systemic lupus erythematosus.

British journal of clinical pharmacology - 1 Oct 2006

Zhong Shilong, Huang Min, Yang Xiuyan, Liang Liuqin, Wang Yixi, Romkes Marjorie, Duan Wei, Chan Eli, Zhou Shu-Feng

Abstract excerpt

AIMS: Cyclophosphamide (CTX) is an established treatment of severe systemic lupus erythematosus (SLE). Cytotoxic CTX metabolites are mainly detoxified by multiple glutathione S-transferases (GSTs). However, data are lacking on the relationship between the short-term side-effects of CTX therapy and GST genotypes. In the present study, the effects of common GSTM1, GSTT1, and GSTP1 genetic mutations on the severity...

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Identifiers

PMID: 16995867
DOI: 10.1111/j.1365-2125.2006.02690.x
PMCID: PMC1885164

Genes

GSTP1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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