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Article

Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights.

Oncotarget - 17 Jun 2025

Nogueira Cleto Dantas, Frota Samuel, Chaves Huylmer Lucena, de Sousa Juliana Cordeiro, Veloso Guilherme de Sousa, Araujo Francisco Jonathan Dos Santos, Silva Gabriel Barbosa, Ferreira Samuel Silva, Alves Marclesson Santos, Nasser Fabio, Rangel Ezequiel, Neto Francisco Martins, Caminha Iusta, Nascimento Ellen, Tavora Fabio

Abstract excerpt

HER2 genomic alterations characterize a specific subset of NSCLC with potential therapeutic relevance. While most studies focus on populations from high-income countries, data from Latin America remains scarce. We retrospectively analyzed 13 HER2-mutated NSCLC cases from a single institution in Northeastern Brazil, integrating clinical, histopathological, immunohistochemical, and molecular findings. Predominant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40526089
DOI: 10.18632/oncotarget.28737
PMCID: PMC12173199

Genes

KRAS
STK11
TP53

Provenance

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