Article
A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).
Breast cancer research : BCR - 1 Jan 2006
Cox David G, Blanché Hélène, Pearce Celeste L, Calle Eugenia E, Colditz Graham A, Pike Malcolm C, Albanes Demetrius, Allen Naomi E, Amiano Pilar, Berglund Goran, Boeing Heiner, Buring Julie, Burtt Noel, Canzian Federico, Chanock Stephen, Clavel-Chapelon Françoise, Feigelson Heather Spencer, Freedman Matthew, Haiman Christopher A, Hankinson Susan E, Henderson Brian E, Hoover Robert, Hunter David J, Kaaks Rudolf, Kolonel Laurence, Kraft Peter, LeMarchand Loic, Lund Eiliv, Palli Domenico, Peeters Petra H M, Riboli Elio, Stram Daniel O, Thun Michael, Tjonneland Anne, Trichopoulos Dimitrios, Yeager Meredith
Abstract excerpt
INTRODUCTION: Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National...
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