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Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation

27 Apr 2024

Abstract excerpt

Caspase-2, a highly conserved member of the caspase family, is considered an initiator caspase that triggers apoptosis in response to some cellular stresses. Previous studies suggest that an intracellular multi-protein complex PIDDosome, induced by genotoxic stress, serves as a platform for caspase-2 activation. Due to caspase-2's inability to process effector caspases, however, the mechanism underlying...

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PMID: 38676703
DOI: 10.1093/procel/pwae020

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