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A Human Cell-Based Assay to Evaluate the Effects of Alterations in the <i>MLH1</i> Mismatch Repair Gene

15 Sept 2006

Abstract excerpt

We describe a new approach to investigate alterations in the human MLH1 mismatch repair (MMR) gene. This is based on complementation of the phenotype of a MLH1-defective subclone of the ovarian carcinoma A2780 cells by transfection of vectors encoding altered MLH1 proteins. Measurements of resistance (tolerance) to methylating agents, mutation rate at HPRT, microsatellite instability (MSI), and steady-state...

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PMID: 16982745
DOI: 10.1158/0008-5472.can-06-1896

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