Article
AccuTyping: new algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays.
Nucleic acids research - 1 Jan 2006
Hu Guohong, Wang Hui-Yun, Greenawalt Danielle M, Azaro Marco A, Luo Minjie, Tereshchenko Irina V, Cui Xiangfeng, Yang Qifeng, Gao Richeng, Shen Li, Li Honghua
Abstract excerpt
Microarray-based analysis of single nucleotide polymorphisms (SNPs) has many applications in large-scale genetic studies. To minimize the influence of experimental variation, microarray data usually need to be processed in different aspects including background subtraction, normalization and low-signal filtering before genotype determination. Although many algorithms are sophisticated for these purposes, biases...
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