Article
Rheumatoid synovial fluid T cells are sensitive to APO2L/TRAIL.
Clinical immunology (Orlando, Fla.) - 1 Jan 2007
Martínez-Lorenzo María José, Anel Alberto, Saez-Gutierrez Berta, Royo-Cañas María, Bosque Alberto, Alava María Angeles, Piñeiro Andrés, Lasierra Pilar, Asín-Ungría Jaime, Larrad Luis
Abstract excerpt
The infiltration and accumulation of T cells in the rheumatoid arthritis (RA) synovial fluid (SF) are hallmarks of disease. We aimed to assess the functional relevance of FasL and of APO2L/TRAIL in the persistence of T cells in the rheumatoid SF. We have analyzed the expression of the activation markers HLA-DR and CD69 and also of the death receptor Fas/CD95 and death ligands FasL or APO2L/TRAIL in CD3+...
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