Article
The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target.
Clinical & developmental immunology - 1 Jan 2012
Chakera Aron, Bennett Sophia C, Morteau Olivier, Bowness Paul, Luqmani Raashid A, Cornall Richard J
Abstract excerpt
Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting synovial joints in which the development of autoantibodies represents a failure of normal tolerance mechanisms, suggesting a role for follicular helper T cells (T(FH)) in the genesis of autoimmunity. To determine whether quantitative or qualitative abnormalities in the circulating T(FH) cell population exist, we analysed by flow...
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