Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice.

doi:10.1016/j.mad.2006.08.003

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Article

Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice.

Mechanisms of ageing and development - 1 Nov 2006

Leiser Scott F, Salmon Adam B, Miller Richard A

Abstract excerpt

Fibroblast cell lines derived from the skin of young adult mice of the long-lived Snell dwarf mutant mouse stock have been shown to be resistant to the cytotoxic effects of multiple agents, including hydrogen peroxide, cadmium, heat, ultraviolet light, and the carcinogen methyl methanesulfonate. Snell dwarf fibroblasts are here reported to differ from control cell lines in two other respects: they are relatively...

Topics

Animals
Cell Line
Cell Proliferation
Cytotoxins
Dwarfism, Pituitary
Female
Fibroblasts
Glucose
Longevity
Male
Mice
Mitochondria
Mutation
Rotenone
Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 16979221
DOI: 10.1016/j.mad.2006.08.003

Provenance

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