Article
Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2001
Ogburn C E, Carlberg K, Ottinger M A, Holmes D J, Martin G M, Austad S N
Abstract excerpt
Previous studies indicated that renal tubular epithelial cells from some long-lived avian species exhibit robust and/or unique protective mechanisms against oxidative stress relative to murine cells. Here we extend these studies to investigate the response of primary embryonic fibroblast-like cells to oxidative challenge in long- and short-lived avian species (budgerigar, Melopsittacus undulatus, longevity up to...
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