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Article

Use of tissue culture models to study environmental-genetic interactions relevant to neurodegenerative diseases.

Clinical and experimental pharmacology & physiology - 1 May 1995

Durham H D, O'Brien C, Nalbantoglu J, Figlewicz D A

Abstract excerpt

1. Clonal cell lines, primary cultured neurones and transgenic animals expressing mutant genes linked to familial forms of neurodegenerative diseases provide models in which to examine the interaction between expression of a predisposing gene and exposure to neurotoxic chemicals. Methods of establishing these models are reviewed. 2. Mutations in the gene encoding Cu/Zn-superoxide dismutase (SOD-1) have been...

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Identifiers

PMID: 7554432
DOI: 10.1111/j.1440-1681.1995.tb02019.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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