Article
Use of tissue culture models to study environmental-genetic interactions relevant to neurodegenerative diseases.
Clinical and experimental pharmacology & physiology - 1 May 1995
Durham H D, O'Brien C, Nalbantoglu J, Figlewicz D A
Abstract excerpt
1. Clonal cell lines, primary cultured neurones and transgenic animals expressing mutant genes linked to familial forms of neurodegenerative diseases provide models in which to examine the interaction between expression of a predisposing gene and exposure to neurotoxic chemicals. Methods of estab...
Topics
- Amyotrophic Lateral Sclerosis
- Animals
- Cell Line
- Cells, Cultured
- Chromosomes, Human, Pair 21
- Clone Cells
- Culture Techniques
- Epoxy Compounds
- Gene Expression Regulation, Enzymologic
- Humans
- Mice
- Mutation
- Neurons
- Neurotoxins
- Oxidation-Reduction
- PC12 Cells
- Rats
- Superoxide Dismutase