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Article

Mapping the antigenic determinants and reducing the immunogenicity of trichosanthin by site-directed mutagenesis.

Journal of biomedical science - 1 Sept 2006

An Qunxing, Wei Sanhua, Mu Shijie, Zhang Xianqing, Lei Yingfeng, Zhang Wei, Jia Ning, Cheng Xiaodong, Fan Ailing, Li Zhidong, Xu Zhikai

Abstract excerpt

Trichosanthin (TCS) is a type I ribosome-inactivating protein (RIP) possessing multiple pharmacological properties. One of its interesting properties is to inhibit human immunodeficiency virus (HIV) replication but its strong immunogenicity has limited the repeated clinical administration. To map the antigenic determinants and reduce the immunogenicity of TCS, two potential antigenic sites (YFF81-83 and...

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Identifiers

PMID: 16977428
DOI: 10.1007/s11373-006-9095-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mapping the antigenic determinants and reducing the immunogenicity of trichosanthin by site-directed mutagenesis.PMID 16977428Read ↗

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