Article
Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Sept 2006
Massironi S M G, Reis B L F S, Carneiro J G, Barbosa L B S, Ariza C B, Santos G C, Guénet J L, Godard A L B
Abstract excerpt
When compared to other model organisms whose genome is sequenced, the number of mutations identified in the mouse appears extremely reduced and this situation seriously hampers our understanding of mammalian gene function(s). Another important consequence of this shortage is that a majority of human genetic diseases still await an animal model. To improve the situation, two strategies are currently used: the...
Topics
- Alkylating Agents
- Alleles
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Ethylnitrosourea
- Female
- Genome
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred NZB
- Mutagenesis