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Mutant erythropoietin enhances white matter repair via the JAK2/STAT3 and C/EBPβ pathway in middle-aged mice following cerebral ischemia and reperfusion.

Experimental neurology - 1 Mar 2021

Wang Rongliang, Zhang Sijia, Yang Zhenhong, Zheng Yangmin, Yan Feng, Tao Zhen, Fan Junfen, Zhao Haiping, Han Ziping, Luo Yumin

Abstract excerpt

Previous studies have indicated that EPO maintains the M2 microglia phenotype that contributes to white matter repair after ischemic stroke in young mice (2 months old). However, the underlying mechanisms that regulate microglial polarization are poorly defined. This study investigated the neuroprotective effects of nonerythropoietic mutant EPO (MEPO) on white matter and the underlying mechanism in middle-aged...

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PMID: 33309747
DOI: 10.1016/j.expneurol.2020.113553

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