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Article

Cross-reactive protection against influenza A virus infections by an NS1-specific CTL clone.

Virology - 1 Sept 1990

Kuwano K, Tamura M, Ennis F A

Abstract excerpt

An influenza A subtype cross-reactive CTL clone (A-11) was established following stimulation of A/PR/8 virus-immune spleen cells of Balb/C (H-2d) mice. This T cell clone lysed target cells infected with influenza viruses of the H1, H2, or H3 subtypes, and recognizes a conserved epitope on the NS1 protein. The clone is restricted by the H-2Ld allele. Adoptive transfer of A-11 significantly reduced virus titers in...

Topics

Alleles
Animals
Capsid
Cell Line
Clone Cells
Cross Reactions
Epitopes
Influenza A virus
Lung
Major Histocompatibility Complex
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Orthomyxoviridae Infections

Viral Core Proteins

Viral Nonstructural Proteins

Source

Identifiers

PMID: 1697125
DOI: 10.1016/0042-6822(90)90391-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1697125-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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