Competence for genetic transformation in Streptococcus pneumoniae: mutations in σA bypass the comW requirement.

Abstract excerpt

Competence for genetic transformation in the genus Streptococcus depends on an alternative sigma factor, σ(X), for coordinated synthesis of 23 proteins, which together establish the X state by permitting lysis of incompetent streptococci, uptake of DNA fragments, and integration of strands of that DNA into the resident genome. Initiation of transient accumulation of high levels of σ(X) is coordinated between...

Topics

• Amino Acid Sequence
• Bacterial Proteins
• DNA, Bacterial
• Gene Expression Regulation, Bacterial
• Models, Molecular
• Molecular Sequence Data
• Mutation
• Protein Conformation
• Sigma Factor
• Streptococcus pneumoniae
• Transformation, Genetic