Article
Positive association of schizophrenia to JARID2 gene.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2007
Pedrosa Erika, Ye Kenny, Nolan Karen A, Morrell Lauren, Okun Jeffrey M, Persky Adam D, Saito Takuya, Lachman Herbert M
Abstract excerpt
Dysbindin (DTNBP1) is a positional candidate gene for 6p22.3-linked schizophrenia (SZ). However, so far, no disease-causing alleles have been identified. DTNBP1 is immediately adjacent to JARID2, a member of the ARID (AT-rich interaction domain) family of transcription modulators. We have previously suggested that proteins which bind to AT-rich domains could play a role in SZ pathogenesis. Consequently, we...
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