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Article

Role of the agonist binding site in up-regulation of neuronal nicotinic alpha4beta2 receptors.

Molecular pharmacology - 1 Dec 2006

Kishi Masashi, Steinbach Joe Henry

Abstract excerpt

Long-term exposure to nicotinic ligands results in up-regulation of neuronal nicotinic alpha4beta2 receptors in the brain and in heterologous expression systems. Up-regulation can be produced by a variety of drugs, including nicotinic agonists and competitive antagonists, but previous studies have indicated that the signal for up-regulation does not reflect a traditional nicotinic pharmacology, and the initial...

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Identifiers

PMID: 16966476
DOI: 10.1124/mol.106.029298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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