Article
Expression profile of <i>LIT1/KCNQ1OT1</i> and epigenetic status at the KvDMR1 in colorectal cancers
5 Sept 2006
Abstract excerpt
The human chromosome region 11p15.5 contains a number of maternally and paternally imprinted genes, and the LIT1/KCNQ1OT1 locus acts as an imprinting center in the proximal domain of 11p15.5. Loss of imprinting (LOI) of LIT1 and its correlation with methylation status at a differentially methylated region, the KvDMR1, were investigated in 69 colorectal cancer tissue specimens. LIT1 expression profiles were also...
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