Article
CYP2C19 polymorphism and risk for essential tremor.
European neurology - 1 Jan 2006
Alonso-Navarro Hortensia, Martínez Carmen, García-Martín Elena, Benito-León Julián, García-Ferrer Isabel, Vázquez-Torres Pilar, Puertas Inmaculada, López-Alburquerque Tomás, Agúndez José A G, Jiménez-Jiménez Félix Javier
Abstract excerpt
Many patients with essential tremor (ET) develop acute adverse effects to primidone. We investigated the association between CYP2C19 polymorphism (possibly related to primidone metabolism) and the risk for developing essential ET and acute adverse effects to primidone. Leukocytary DNA from 200 ET patients and 300 healthy controls was studied for the genotype CYP2C19 and the occurrence of CYP2C19 allelic variants...
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