Article
DNA variation of the mammalian major histocompatibility complex reflects genomic diversity and population history.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Yuhki N, O'Brien S J
Abstract excerpt
The major histocompatibility complex (MHC) is a multigene complex of tightly linked homologous genes that encode cell surface antigens that play a key role in immune regulation and response to foreign antigens. In most species, MHC gene products display extreme antigenic polymorphism, and their v...
Topics
- Animals
- Carnivora
- Cats
- Cricetinae
- DNA
- Genes, MHC Class I
- Genetic Variation
- Humans
- Lions
- Major Histocompatibility Complex
- Mathematics
- Mesocricetus
- Mice
- Mice, Inbred Strains
- Models, Genetic
- Organ Specificity
- Polymorphism, Restriction Fragment Length
- Species Specificity