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Article

DNA variation of the mammalian major histocompatibility complex reflects genomic diversity and population history.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990

Yuhki N, O'Brien S J

Abstract excerpt

The major histocompatibility complex (MHC) is a multigene complex of tightly linked homologous genes that encode cell surface antigens that play a key role in immune regulation and response to foreign antigens. In most species, MHC gene products display extreme antigenic polymorphism, and their variability has been interpreted to reflect an adaptive strategy for accommodating rapidly evolving infectious agents...

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Identifiers

PMID: 1967831
DOI: 10.1073/pnas.87.2.836
PMCID: PMC53361

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