Neddylation positively regulates the ubiquitin E3 ligase activity of parkin.

Abstract excerpt

Mutations in the parkin gene underlie a familial form of Parkinson's disease known as autosomal recessive juvenile Parkinsonism (AR-JP). Dysfunction of parkin, a ubiquitin E3 ligase, has been implicated in the accumulation of ubiquitin proteasome system-destined substrates and eventually leads to cell death. However, regulation of parkin enzymatic activity is incompletely understood. Here we investigated whether...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cycloheximide
• Share to Leupeptins
• Share to Neuroblastoma