Article
Growth differentiating factor-9 mutations may be associated with premature ovarian failure.
Fertility and sterility - 1 Jan 2007
Kovanci Ertug, Rohozinski Jan, Simpson Joe Leigh, Heard Michael J, Bishop Colin E, Carson Sandra A
Abstract excerpt
OBJECTIVE: To determine whether perturbations of the growth differentiating factor-9 (GDF9) gene are associated with premature ovarian failure (POF). DESIGN: Mutational analysis of the GDF9 gene in 61 women with POF. SETTING: Academic institution. PATIENT(S): Sixty-one women with POF; 60 control women. INTERVENTION(S): Peripheral blood sampling, genomic DNA extraction, mutational screening, and DNA sequencing....
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