Article
Localization of four antigenic sites involved in Venezuelan equine encephalomyelitis virus protection.
Archives of virology - 1 Jan 1994
Agapov E V, Razumov I A, Frolov I V, Kolykhalov A A, Netesov S V, Loktev V B
Abstract excerpt
Stable neutralization and protection escape variants of a virulent strain (Trinidad Donkey) of the VEE virus were selected by monoclonal antibodies (MAbs). Determination of nucleotide sequences of nine variants revealed a clustering of single mutations in four regions of the E1 and E2 glycoproteins. Involvement of amino acid residues 206 (site E1-1), 57 and 59 (site E2-2), 180, 182, 213, 214 and 216 (site E2-6)...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Capsid
- Chlorocebus aethiops
- Codon
- Encephalitis Virus, Venezuelan Equine
- Epitopes
- Genetic Variation
- Mice
- Molecular Sequence Data
