Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically engineered, live attenuated vaccines for Venezuelan equine encephalitis: testing in animal models.

Vaccine - 8 Sept 2003

Pratt William D, Davis Nancy L, Johnston Robert E, Smith Jonathan F

Abstract excerpt

The central objective of this research was to test molecularly defined, live attenuated Venezuelan equine encephalitis virus (VEEV) vaccine candidates that were produced through precise genetic manipulation of rationally selected viral nucleotide sequences. Molecular clones of vaccine candidates were constructed by inserting either three independently attenuating mutations or a PE2 cleavage-signal mutation with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Viral
Share to Cricetinae
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Macaca fascicularis

Share to Mesocricetus

Share to Protein Engineering

Share to Vaccines, Attenuated

Share to Viral Vaccines

Source

Identifiers

PMID: 12922119
DOI: 10.1016/s0264-410x(03)00328-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically engineered, live attenuated vaccines for Venezuelan equine encephalitis: testing in animal models.PMID 12922119Read ↗

Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinantsSemantic proximity Read ↗

Genetically engineered, live, attenuated vaccines protect nonhuman primates against aerosol challenge with a virulent IE strain of Venezuelan equine encephalitis virusSemantic proximity Read ↗

Directed molecular evolution improves the immunogenicity and protective efficacy of a Venezuelan equine encephalitis virus DNA vaccineSemantic proximity Read ↗

Novel DNA-launched Venezuelan equine encephalitis virus vaccine with rearranged genomeSemantic proximity Read ↗

Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Mouse ModelSemantic proximity Read ↗

Attenuating mutations in the E2 glycoprotein gene of Venezuelan equine encephalitis virus: Construction of single and multiple mutants in a full-length cDNA cloneSemantic proximity Read ↗

Development and characterization of an infectious cDNA clone of the modified live virus vaccine strain of equine arteritis virus.Semantic proximity Read ↗

Attenuated Mutants of Venezuelan Equine Encephalitis Virus Containing Lethal Mutations in the PE2 Cleavage Signal Combined with a Second-Site Suppressor Mutation in E1Semantic proximity Read ↗

IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells.Semantic proximity Read ↗

Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.Semantic proximity Read ↗

In Vitro and In Vivo Phenotypes of Venezuelan, Eastern and Western Equine Encephalitis Viruses Derived from cDNA Clones of Human Isolates.Semantic proximity Read ↗

Recombinant Sindbis/Venezuelan Equine Encephalitis Virus Is Highly Attenuated and ImmunogenicSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.