Genetically engineered, live attenuated vaccines for Venezuelan equine encephalitis: testing in animal models.

doi:10.1016/s0264-410x(03)00328-1

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Article

Genetically engineered, live attenuated vaccines for Venezuelan equine encephalitis: testing in animal models.

Vaccine - 8 Sept 2003

Pratt William D, Davis Nancy L, Johnston Robert E, Smith Jonathan F

Abstract excerpt

The central objective of this research was to test molecularly defined, live attenuated Venezuelan equine encephalitis virus (VEEV) vaccine candidates that were produced through precise genetic manipulation of rationally selected viral nucleotide sequences. Molecular clones of vaccine candidates were constructed by inserting either three independently attenuating mutations or a PE2 cleavage-signal mutation with a...

Topics

Animals
Antibodies, Viral
Cloning, Molecular
Cricetinae
DNA, Complementary
Encephalitis Virus, Venezuelan Equine
Encephalomyelitis, Venezuelan Equine
Female
Macaca fascicularis
Mesocricetus
Mice
Mice, Inbred C57BL
Mutation
Protein Engineering
Vaccines, Attenuated
Viral Vaccines

Source

Open in PubMed

Identifiers

PMID: 12922119
DOI: 10.1016/s0264-410x(03)00328-1

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