Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta -87T>C polymorphism and dietary fat in French-Canadians.

Abstract excerpt

OBJECTIVE: We verified whether genetic variants in this gene are associated with the MS and whether dietary fatty acids interact with the -87T>C polymorphism. METHODS: By direct sequencing, we identified 15 variants in the PPAR-delta gene and analyses were pursued with the -87T>C polymorphism for 340 subjects. RESULTS: Metabolic variables were comparable among each genotype group. The -87T>C polymorphism, fat...

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