Article
KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression.
Oncogene - 4 Jan 2007
Oliveira C, Velho S, Moutinho C, Ferreira A, Preto A, Domingo E, Capelinha A F, Duval A, Hamelin R, Machado J C, Schwartz S, Carneiro F, Seruca R
Abstract excerpt
In sporadic colorectal cancer (CRC), KRAS are alternative to BRAF mutations and occur, respectively, in 30 and 10% of cases. Few reports addressed the association between KRAS-BRAF mutations and tumour progression specifically in sporadic microsatellite-stable (MSS) CRC. We screened KRAS and BRAF in 250 MSS primary CRC and 45 lymph node (LN) metastases and analysed the pathological features of the cases to...
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