Article
Inhibition of monoamine oxidase A promotes secretory differentiation in basal prostatic epithelial cells.
Differentiation; research in biological diversity - 1 Sept 2008
Zhao Hongjuan, Nolley Rosalie, Chen Zuxiong, Reese Stephen W, Peehl Donna M
Abstract excerpt
Monoamine oxidase A (MAO-A) expression is associated with high-grade prostate cancer. Immunohistochemistry showed that MAO-A is also expressed in the basal epithelial cells of normal prostate glands. Using cultured primary prostatic epithelial cells as a model, we showed that MAO-A prevents basal epithelial cells from differentiating into secretory cells. Under differentiation-promoting conditions, clorgyline, an...
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