Article
A1 adenosine receptors in microglia control glioblastoma-host interaction.
Cancer research - 1 Sept 2006
Synowitz Michael, Glass Rainer, Färber Katrin, Markovic Darko, Kronenberg Golo, Herrmann Ken, Schnermann Juergen, Nolte Christiane, van Rooijen Nico, Kiwit Juergen, Kettenmann Helmut
Abstract excerpt
We report that experimental glioblastoma grow more vigorously in A(1) adenosine receptor (A(1)AR)-deficient mice associated with a strong accumulation of microglial cells at and around the tumors. A(1)ARs were prominently expressed in microglia associated with tumor cells as revealed with immunocytochemistry but low in microglia in the unaffected brain tissue. The A(1)AR could also be detected on microglia from...
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