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Article

Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.

Biochemical and biophysical research communications - 20 Oct 2006

Ohta Akihito, Yang Sung-Sen, Rai Tatemitsu, Chiga Motoko, Sasaki Sei, Uchida Shinichi

Abstract excerpt

Pseudohypoaldosteronism type II (PHAII), an autosomal dominant disorder characterized by hypertension, hyperkalemia, and hyperchloremic acidosis, is reportedly due to mutations in WNK1 and WNK4 kinase genes. However, the pathogenesis of the disease remains unknown. Mutations in the WNK1 gene are...

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Source

Identifiers

PMID: 16949040
DOI: 10.1016/j.bbrc.2006.08.101

Genes

WNK1
WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16949040-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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