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Article

Model-Based Design of Growth-Attenuated Viruses

29 Aug 2006

Abstract excerpt

Live-virus vaccines activate both humoral and cell-mediated immunity, require only a single boosting, and generally provide longer immune protection than killed or subunit vaccines. However, growth of live-virus vaccines must be attenuated to minimize their potential pathogenic effects, and mechanisms of attenuation by conventional serial-transfer viral adaptation are not well-understood. New methods of...

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PMID: 16948530
DOI: 10.1371/journal.pcbi.0020116

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