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Article

Role of lgtC in Resistance of Nontypeable Haemophilus influenzae Strain R2866 to Human Serum

20 Oct 2006

Abstract excerpt

We are investigating a nontypeable Haemophilus influenzae (NTHI) strain, R2866, isolated from a child with meningitis. R2866 is unusually resistant to killing by normal human serum. The serum 50% inhibitory concentration (IC50) for this strain is 18%, approaching that of encapsulated H. influenzae. R3392 is a derivative of R2866 that was found to have increased sensitivity to human serum (IC50, 1.5%). Analysis of...

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PMID: 16966407
DOI: 10.1128/iai.00722-06

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