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Article

Characterization of two transposon mutants from Haemophilus influenzae type b with altered lipooligosaccharide biosynthesis.

Biochemistry - 7 May 1996

Phillips N J, McLaughlin R, Miller T J, Apicella M A, Gibson B W

Abstract excerpt

Two isogenic mutants of Haemophilus influenzae type b (Hib) strain A2 were prepared by random m-Tn3(Cm) insertions into the 7.4-kb lsg (lipooligosaccharide synthesis genes) region of Hib DNA, which consists of seven complete and one partial open reading frame (orfs). Compared to the parent A2 strain which produces a complex mixture of lipooligosaccharides (LOS), the mutant strains 281.25 and 276.4 produced only a...

Topics

Antigens, Bacterial
Base Sequence
Carbohydrate Sequence
DNA Primers
DNA Transposable Elements
DNA, Bacterial
Escherichia coli
Haemophilus influenzae
Lipopolysaccharides
Mass Spectrometry
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Structure

Mutagenesis, Insertional

Mutation

Source

Identifiers

PMID: 8639556
DOI: 10.1021/bi960059b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8639556-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of two transposon mutants from Haemophilus influenzae type b with altered lipooligosaccharide biosynthesis.PMID 8639556Read ↗

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