Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CAG*CTG repeat instability in cultured human astrocytes.

Nucleic acids research - 1 Jan 2006

Farrell Brian T, Lahue Robert S

Abstract excerpt

Cells of the central nervous system (CNS) are prone to the devastating consequences of trinucleotide repeat (TNR) expansion. Some CNS cells, including astrocytes, show substantial TNR instability in affected individuals. Since astrocyte enrichment occurs in brain regions sensitive to neurodegeneration and somatic TNR instability, immortalized SVG-A astrocytes were used as an ex vivo model to mimic TNR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Astrocytes
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 16945950
DOI: 10.1093/nar/gkl614
PMCID: PMC1636369

Genes

TNR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CAG*CTG repeat instability in cultured human astrocytes.PMID 16945950Read ↗

Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats.Semantic proximity Read ↗

Replication in mammalian cells recapitulates the locus-specific differences in somatic instability of genomic GAA triplet-repeats.Semantic proximity Read ↗

Progressive telomere shortening occurs in cultured rat microglia, but not astrocytesSemantic proximity Read ↗

Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells.Semantic proximity Read ↗

Mouse tissue culture models of unstable triplet repeats: in vitro selection for larger alleles, mutational expansion bias and tissue specificity, but no association with cell division rates.Semantic proximity Read ↗

Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair.Semantic proximity Read ↗

Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation.Semantic proximity Read ↗

Replication and expansion of trinucleotide repeats in yeast.Semantic proximity Read ↗

Stepwise transformation of astrocytes by simian virus 40 large T antigen and epidermal growth factor receptor overexpression.Semantic proximity Read ↗

HIV and drug abuse mediate astrocyte senescence in a β‐catenin‐dependent manner leading to neuronal toxicitySemantic proximity Read ↗

Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas.Semantic proximity Read ↗

Genetic instabilities of (CCTG).(CAGG) and (ATTCT).(AGAAT) disease-associated repeats reveal multiple pathways for repeat deletion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.