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Article

Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells.

Molecular and cellular biology - 1 Jul 2003

Gorbunova Vera, Seluanov Andrei, Dion Vincent, Sandor Zoltan, Meservy James L, Wilson John H

Abstract excerpt

Despite substantial progress in understanding the mechanism by which expanded CTG/CAG trinucleotide repeats cause neurodegenerative diseases, little is known about the basis for repeat instability itself. By taking advantage of a novel phenomenon, we have developed a selectable assay to detect contractions of CTG/CAG triplets. When inserted into an intron in the APRT gene or the HPRT minigene, long tracts of...

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Identifiers

PMID: 12808091
DOI: 10.1128/MCB.23.13.4485-4493.2003
PMCID: PMC164839

Genes

APRT

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