Article
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.
Proceedings of the National Academy of Sciences of the United States of America - 19 Sept 2006
Freedman Matthew L, Haiman Christopher A, Patterson Nick, McDonald Gavin J, Tandon Arti, Waliszewska Alicja, Penney Kathryn, Steen Robert G, Ardlie Kristin, John Esther M, Oakley-Girvan Ingrid, Whittemore Alice S, Cooney Kathleen A, Ingles Sue A, Altshuler David, Henderson Brian E, Reich David
Abstract excerpt
A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (P < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate...
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