Article
Occurrence of both breast and ovarian cancer in a woman is a marker for the BRCA gene mutations: a population-based study from western Sweden.
Familial cancer - 1 Jan 2007
Einbeigi Zakaria, Bergman Annika, Meis-Kindblom Jeanne M, Flodin Anna, Bjursell Cecilia, Martinsson Tommy, Kindblom Lars-Gunnar, Wahlström Jan, Wallgren Arne, Nordling Margareta, Karlsson Per
Abstract excerpt
AIM: This study aimed to analyze whether the occurrence of both breast and ovarian cancer in a woman serves as a marker for BRCA gene mutations. MATERIAL AND METHODS: This population-based study included 256 women in western Sweden who developed both invasive breast and ovarian tumors between 1958 and 1999. Archival paraffin tissue blocks of their tumors were retrieved for DNA-extraction to analyze the founder...
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