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Article

Adeno-associated virus serotype 6 capsid tyrosine-to-phenylalanine mutations improve gene transfer to skeletal muscle.

Human gene therapy - 1 Oct 2010

Qiao Chunping, Zhang Wei, Yuan Zhenhua, Shin Jin-Hong, Li Jianbin, Jayandharan Giridhara R, Zhong Li, Srivastava Arun, Xiao Xiao, Duan Dongsheng

Abstract excerpt

Adeno-associated viral (AAV) vectors are the most efficient in vivo gene transfer tools for gene therapy applications. Efforts have been made to translate encouraging results in small animal models to human patients. However, the need for large quantities of vector for clinical application remains a great challenge. Developing novel AAV vectors with enhanced infectivity may reduce the high vector dose requirement...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20497037
DOI: 10.1089/hum.2010.003
PMCID: PMC2957235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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