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Tetracycline analogue-regulated transgene expression in <i>Plasmodium falciparum</i> blood stages using <i>Toxoplasma gondii</i> transactivators

14 Feb 2005

Abstract excerpt

Genetic manipulation has revolutionized research in the Apicomplexan parasite Plasmodium falciparum, the most important causative agent of malaria. However, to date no techniques have been established that allow modifications that are deleterious to blood-stage growth, such as the disruption of essential genes or the expression of dominant-negative transgenes. The recent establishment of a screen for functional...

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PMID: 15710888
DOI: 10.1073/pnas.0500112102

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