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Article

The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases.

Biochimica et biophysica acta - 11 Nov 2002

Kallen Karl-Josef

Abstract excerpt

The activation of cells that do not express the membrane bound interleukin-6 6 receptor (IL-6R) by IL-6 and the soluble IL-6 receptor (sIL-6R) is termed transsignalling. Transsignalling may be an pathogenetic factor in human diseases as diverse as multiple myeloma (MM), Castleman's disease, prostate carcinoma, Crohn's disease, systemic sclerosis, Still's disease, osteoporosis and cardiovascular diseases. IL-6 and...

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Identifiers

PMID: 12421676
DOI: 10.1016/s0167-4889(02)00325-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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