Article
Sarcoidosis and NOD1 variation with impaired recognition of intracellular Propionibacterium acnes.
Biochimica et biophysica acta - 1 Sept 2006
Tanabe Tsuyoshi, Ishige Ikuo, Suzuki Yoshimi, Aita Yukie, Furukawa Asuka, Ishige Yuki, Uchida Keisuke, Suzuki Takashige, Takemura Tamiko, Ikushima Soichiro, Oritsu Masaru, Yokoyama Tetsuji, Fujimoto Yukari, Fukase Koichi, Inohara Naohiro, Nunez Gabriel, Eishi Yoshinobu
Abstract excerpt
Sarcoidosis is a systemic granulomatous disease of unknown etiology. NOD2 mutations have been shown to predispose to granulomatous diseases, including Crohn's disease, Blau syndrome, and early-onset sarcoidosis, but not to adult sarcoidosis. We found that intracellular Propionibacterium acnes, a possible causative agent of sarcoidosis, activated NF-kappaB in both NOD1- and NOD2-dependent manners. Systematic...
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