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Article

Protective Antiviral Immunity Conferred by a Nonintegrative Lentiviral Vector-Based Vaccine

19 Dec 2008

Abstract excerpt

Lentiviral vectors are under intense scrutiny as unique candidate viral vector vaccines against tumor and aggressive pathogens because of their ability to initiate potent and durable specific immune responses. Strategies that alleviate safety concerns will facilitate the clinical developments involving lentiviral vectors. In this respect, the development of integration deficient lentiviral vectors circumvents the...

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PMID: 19096527
DOI: 10.1371/journal.pone.0003973

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