Article
Relationship between the diversity of the cagA gene of Helicobacter pylori and gastric cancer in Okinawa, Japan.
Journal of gastroenterology - 1 Jul 2006
Satomi Satoko, Yamakawa Akiyo, Matsunaga Shinsuke, Masaki Ryuho, Inagaki Tomoko, Okuda Tomoyuki, Suto Hiroyuki, Ito Yoshiyuki, Yamazaki Yukinao, Kuriyama Masaru, Keida Yoshihide, Kutsumi Hiromu, Azuma Takeshi
Abstract excerpt
BACKGROUND: Helicobacter pylori CagA protein is considered to be one of the virulence factors associated with gastric cancer. CagA is injected into gastric epithelial cells, undergoes tyrosine phosphorylation, and binds to Src homology 2 domain-containing protein-tyrosine phosphatase (SHP-2). Two major subtypes of CagA have been observed in the SHP-2-binding site, the Western and East Asian types. The East...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antigens, Bacterial
- Bacterial Proteins
- Duodenal Ulcer
- Female
- Genetic Variation
- Helicobacter Infections
- Helicobacter pylori