Article
Influences of long-term antibiotic administration on Peyer's patch lymphocytes and mucosal immunoglobulin A levels in a mouse model.
JPEN. Journal of parenteral and enteral nutrition - 1 Jan 2000
Yaguchi Yoshihisa, Fukatsu Kazuhiko, Moriya Tomoyuki, Maeshima Yoshinori, Ikezawa Fumie, Omata Jiro, Ueno Chikara, Okamoto Koichi, Hara Etsuko, Ichikura Takashi, Hiraide Hoshio, Mochizuki Hidetaka, Touger-Decker Riva E
Abstract excerpt
BACKGROUND: Long-term antibiotic administration is sometimes necessary to control bacterial infections during the perioperative period. However, antibiotic administration may alter gut bacterial flora, possibly impairing gut mucosal immunity. We hypothesized that 1 week of subcutaneous (SC) antibiotic injections would affect Peyer's patch (PP) lymphocyte numbers and phenotypes, as well as mucosal immunoglobulin A...
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