Article
Multiple intestinal 'loops' provide an in vivo model to analyse multiple mucosal immune responses.
Journal of immunological methods - 1 Oct 2001
Gerdts V, Uwiera R R, Mutwiri G K, Wilson D J, Bowersock T, Kidane A, Babiuk L A, Griebel P J
Abstract excerpt
Mucosal immunity plays an important role in preventing disease but the induction of protective mucosal immune responses remains a significant challenge. We describe a novel in vivo model to analyze the induction of multiple mucosal immune responses in the small intestine. A sterile segment of intestine ('intestinal-segment'; 2-3 m long) was surgically prepared in the jejunum of 4-6-month-old lambs. This...
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