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A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity

5 Sept 2017

Abstract excerpt

Broad-spectrum antibiotics are frequently prescribed to children. Early childhood represents a dynamic period for the intestinal microbial ecosystem, which is readily shaped by environmental cues; antibiotic-induced disruption of this sensitive community may have long-lasting host consequences. Here we demonstrate that a single pulsed macrolide antibiotic treatment (PAT) course early in life is sufficient to lead...

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PMID: 28894149
DOI: 10.1038/s41467-017-00531-6

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