Article
Coexistence of the K65R/L74V and/or K65R/T215Y mutations on the same HIV-1 genome.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Nov 2006
Henry Mireille, Tourres Christian, Colson Philippe, Ravaux Isabelle, Poizot-Martin Isabelle, Tamalet Catherine
Abstract excerpt
OBJECTIVE: To determine to which extent the mutations K65R, L74V/I and T215Y/F are linked to the same HIV-1 genome. METHODS: Retrospective analysis of the Marseille database (8866 sequences from 3720 patients). The HIV-1 pol gene from four patients' viruses harbouring the double mutant (pure species or genotypic mixtures) was amplified, cloned and sequenced. RESULTS: The four patients had a mean viral load of 5.6...
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